Mammalian SH2-Containing Protein Tyrosine Phosphatases

The SH2-containing protein tyrosine phosphatases References have been implicated as important regulators of signal DeFranco, A., and Law, D. (1995). Tyrosine phosphatases and the transduction (DeFranco and Law, 1995; Imboden and antibody response. Science 268, 263–264. Koretsky, 1995). Currently, there are two mammalian Imboden, J.B., and Koretsky, G.A. (1995). Switching off signals. Curr. members to this PTPase subfamily. They have a comBiol. 5, 727–729. mon structure consisting of two amino-terminal SH2 domains followed by a catalytic domain and a short tail. Owing to the independent isolation by several laboratories of the cDNAs encoding these phosphatases, a wide variety of names have been used in the literature. To facilitate thedissemination of informationconcerning these phosphatases, as investigators that have cloned cDNAs for mammalian SH2-containing phosphatase, we propose the name changes that follow. SHP-1 GenBank accession numbers are M68902, M77273, M90388, X62055; HGMW designation is PTPN6. SHP-1 has been previously known as SHPTP-1, SHP, HCP, and PTP1C. SHP-2 GenBank accession numbers are D13540, L03535, L07527, X70766, LO8663; HGMW designation is PTPN11. SHP-2 has been previously known as SHPTP-2, SHPTP-3, syp, PTP2C, and PTP1D. We would like to recommend that the names SHP-1 and SHP-2 be used in future publications.